BILLERICA, Mass. — Nirrin Technologies has launched TALOS, a direct protein quantitation system designed for biopharmaceutical development and manufacturing workflows.
The Billerica-based company said TALOS is built on its proprietary High-Precision Tunable Laser Spectroscopy technology and is intended to simplify protein quantitation across bioprocessing workflows, from harvest through downstream processing and final formulation.
The system replaces traditional variable pathlength UV workflows with fixed-path near-infrared measurement of the peptide backbone. Nirrin said TALOS can quantify protein concentrations from 0.1 mg/mL to 250 mg/mL in seconds using a 15 µL sample, without dilution, moving optical systems, molecule-specific calibration or manual pathlength adjustment.
Nirrin said the system is designed for use from early process development through GMP manufacturing and can support at-line, in-line and in situ deployment modes. The company said the approach is intended to improve consistency across users, unit operations, scales and manufacturing sites.
“Protein quantitation is performed throughout biopharmaceutical development and manufacturing, but traditional UV-based workflows introduce operational complexity and have limited deployment options, making it difficult to leverage across unit operations and scales,” said Bryan Hassell, Ph.D., CEO of Nirrin Technologies. “As biologics manufacturing becomes more distributed, automated, and data-driven, the need for consistent, transferable protein quantitation across workflows and facilities becomes increasingly important. TALOS™ is designed for modern biologics manufacturing. The system provides a more reliable and transferable approach to protein quantitation that simplifies operation, reduces workflow burden, and delivers consistent measurements across teams, manufacturing sites, and deployment environments.”
The company said TALOS supports protein quantitation across a wide concentration range, including high-concentration formulation without dilution. The system uses a common quantitation architecture intended to support method transferability from process development through GMP manufacturing.
Nirrin said TALOS uses fixed-path measurement architecture to enable repeatable operation across users and sites. The system’s targeted near-infrared measurement of the peptide backbone is designed to reduce dependence on molecule-specific calibration workflows, while built-in spectral residual and measurement quality metrics support method monitoring.
The company said TALOS also includes integrated hardware, software and analytics to simplify deployment and validation. The platform is designed to support audit-ready, GMP-aligned and 21 CFR Part 11-capable workflows.
Unlike variable pathlength UV systems, which rely on moving optical components and slope-based calculations, TALOS directly measures molecular vibrations associated with the peptide backbone in the near-infrared combination-band region through a fixed 1 mm optical pathlength, according to Nirrin.
The at-line configuration of TALOS is currently available. Nirrin said in-line flow cell and in situ probe configurations are in development to support continuous, real-time protein monitoring during processing without sampling.
